Semaglutide

Semaglutide is the active ingredient in Ozempic, Rybelsus, and Wegovy. While Ozempic and Rybelsus treat type 2 diabetes, Wegovy, FDA-approved in 2021, is used for chronic weight management with convenient once-weekly injections.

Our clinic utilizes an enhanced version of Semaglutide by combining it with L-Carnitine, an amino acid that improves effectiveness by helping with fat mobilization. L-Carnitine plays a key role in converting stored fat into energy, making it a powerful addition to your weight loss journey. This combination supports overall weight loss management by boosting fat burning and helping your body achieve its full potential.

Semaglutide is dose dependent and influenced by duration of use. Uptiration of medication will most likely be required for further weightloss over an extended period of time.

Although both medications are GLP-1 medications; semaglutide has longer lasting effects that allows it to be injected once weekly vs. daily dosing that is required with liraglutide.

Patients with chronic kidney disease (CKD) or renal impairment are at an increased risk for acute kidney injury (AKI) and worsened renal failure. For this reason, patent with known history of kidney disease, would not recommend this therapy without appropriate consultation to nephrologist (kidney specialist).

This medication is contraindicated in patients with known hypoglycemia or type 1 diabetes mellitus (DM1) as it could worsen hypoglycemic (low blood sugar) episodes.

Yes. Tirzepatide may be consider a suitable next best option. Decision will be determined at follow-up appointment with updated plan of care.

Medication is not recommended in any patients with a personal history or family history of medullary thyroid cancer (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2); condition that causes tumors in more than one gland in the body).

When used for the treatment of diabetes mellitus or weight loss management, semaglutide should be discontinued for ≥2 months prior to becoming pregnant.

Medications for weight loss therapy are not recommended at conception

Most common side effects include gastrointestinal (GI) symptoms such as nausea, diarrhea, constipation, vomiting. This is the primary reason that these medications are up-titrated (increased over periods of time). It helps introduce them to the body and reduce side effects that could disrupt the medication therapy and impede weightloss.

Administer by SUBQ injection into the abdomen, thigh, or upper arm at any time of day on the same day each week, with or without food. If changing the day of administration is necessary, allow ≥48 hours between 2 doses. Rotate injection sites weekly if injecting in the same area of the body. Do not mix with other products (administer as separate injections). Avoid adjacent injections if administering other agents in the same area of the body. Solution should be clear; do not use if particulate matter and coloration are seen.

Certain foods can interfere with your weight loss goals while taking Semaglutide. To get the most out of your treatment, consider limiting or avoiding the following:

1. High-Sugar Foods

• Avoid candies, sugary drinks, cakes, and pastries. These can spike your blood sugar levels and hinder weight loss progress, making it harder for Semaglutide to regulate appetite and cravings.

2. Processed Foods

• Fast food, chips, and packaged snacks are often high in unhealthy fats and empty calories, which can work against your weight loss efforts and increase hunger.

3. Refined Carbs

• Steer clear of white bread, pasta, and baked goods made with refined flour. These foods can cause blood sugar fluctuations, leading to increased cravings and lower energy levels.

4. Fried Foods

• Foods like french fries, fried chicken, and donuts are high in unhealthy fats and calories, which can slow down weight loss and contribute to digestive discomfort.

5. Alcohol

• Alcoholic beverages can add empty calories and impair your judgment when it comes to healthy food choices. Drinking alcohol in excess may also affect how Semaglutide regulates blood sugar levels.

6. High-Fat Dairy

• Limit full-fat dairy products like cream, cheese, and whole milk as they are calorie-dense and may slow down your progress, despite offering some nutritional benefits.

Avoiding these foods while on Semaglutide can help you stay on track, improve your weight loss results, and support your overall health.

Foods high in protein, particularly plant protein; Provide necessary protein required by the body, help aid ongoing weightloss, maintain muscle and help make you feel fuller for a longer period of time.

Read more about Diet while on semaglutide.

Medications like Semaglutide work differently for each person, but on average, patients experience significant weight loss. Most individuals can expect a 15.8% reduction in baseline body weight with Semaglutide treatment.

Expected Results by Group:

Individuals without Type 2 Diabetes: Clinical trials showed an impressive 14-16% average weight loss from baseline.

Individuals with Type 2 Diabetes: Patients typically saw an average reduction of 9.6% in baseline weight, making it an effective tool for managing weight alongside diabetes.

Women Outperform Men: Women in clinical trials tended to see even greater weight loss results than men.

Semaglutide provides consistent, life-changing outcomes for those committed to long-term weight management and overall wellness.

The Semaglutide injection is an FDA-approved medication designed to aid weight loss by mimicking a hormone in your body called GLP-1. It helps regulate appetite, reduces cravings, and slows digestion, making you feel fuller for longer. This promotes healthy weight loss when paired with lifestyle changes.

Semaglutide stands out due to its high efficacy and long-lasting effects. Compared to other weight loss medications, it provides consistent results and is clinically proven to help patients lose significant weight over time when combined with a healthy diet and exercise.

Semaglutide injections are ideal for adults with a BMI of 27 or higher who have weight-related health conditions or a BMI of 30 or more. A consultation at Tried and True Weightloss can help determine if this treatment is right for you.

Semaglutide injections not only support weight loss but also improve metabolic health, lower blood sugar levels, and reduce the risk of obesity-related conditions like Type 2 diabetes and heart disease. They can be a powerful tool for achieving sustainable weight management.

Common side effects include nausea, vomiting, or mild digestive discomfort, which typically subside as your body adjusts to the medication. Our team ensures a slow titration process to minimize side effects and improve your comfort.

Semaglutide is a simple, self-administered injection taken once a week. During your initial consultation, we’ll teach you how to use the medication safely and effectively as part of your personalized treatment plan.